Universita degli Studi di Modena e Reggio Emilia

Prof. Dr. Michele Zoli
Via Cami 287
Modena 41100
Italy

Prof. Dr. Michele Zoli applies morphological, neurochemical, lesion and behavioral techniques to in vivo models of nAChR pathophysiology (e.g., nicotine addiction, neurodegenerative diseases) and in vivo testing of new nicotinic compounds. Further research interests of the Group include: 1. Functions of dentate gyrus adult neurogenesis; 4. Epigenetic mechanism s of neuronal plasticity in central circuits.

Technologies in use: Quantitative morphological techniques (immunocytochemistry, in situ hybridization, receptor autoradiography, computerized image analysis); ex vivo and in vivo neurochemical measurements (receptor binding and expression, single and double probe in vivo microdialysis); use of neurotoxic lesions; behavioural techniques relevant to the study of nicotine addiction and cognitive properties; gene profiling techniques (suppressive subtraction hybridization, Affymetrix microarrays, microfluidic cards, real-time PCR).